class A penicillin-binding protein 1A/1B, contributes to cell elongation and cell division
function
bifunctional glucosyltransferase/ transpeptidase
product
penicillin-binding protein 1A/1B
Genomic Context
categories
[category|SW 1|Cellular processes] → [category|SW 1.1|Cell envelope and cell division] → [category|SW 1.1.1|Cell wall synthesis] → [category|SW 1.1.1.7|Penicillin-binding proteins][category|SW 1|Cellular processes] → [category|SW 1.1|Cell envelope and cell division] → [category|SW 1.1.2|Cell shape][category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.2|Cell envelope stress proteins (controlled by SigM, V, W, X, Y)][category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]Gene
Coordinates
2,341,444 → 2,344,188
Phenotypes of a mutant
prevents bulging of the cells when grown at low Mg(2 ) concentrations, suppresses the lethal effect of a ''[gene|A4C8719E06F774A6EB4D79757CC79CF89E453A54|mreB]'' mutation [Pubmed|19192185]deletion of ''ponA'' restores growth and normal shape of a ''[gene|7150BABA5086D5E2EB8102E4901A216F43576282|glmR]'' mutant on gluconeogenic carbon sources [Pubmed|21320184]The protein
[SW|Localization]
membrane associated [Pubmed|18763711]localizes to the spore septum during sporulation [Pubmed|15758244,15262952]localizes to the vegetative septum [Pubmed|15262952], this depends on [protein|7150BABA5086D5E2EB8102E4901A216F43576282|GlmR] [Pubmed|21320184]Expression and Regulation
Operons
genes
[gene|ED1E2011C7E43A8B7E9FD9A471BC11B9DEA73177|recU]-[gene|A8EEC896B279CFDDE9C3A6F146A04EC822E33A4F|ponA]
description
[Pubmed|7814321]
sigma factors
[protein|081DF3EE9FA56209D648C7677188C61CE3AA8E41|SigM]: sigma factor, [Pubmed|18179421], in [regulon|081DF3EE9FA56209D648C7677188C61CE3AA8E41|SigM regulon][protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA]: sigma factor, [Pubmed|22211522], in [regulon|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA regulon]regulation
constitutive during vegetative growth [Pubmed|15758244]view in new tabBiological materials
two-hybrid system
''B. pertussis'' adenylate cyclase-based bacterial two hybrid system ([SW|BACTH]), available in [SW|Jeff Errington] labLabs working on this gene/protein
[SW|Jeff Errington], Newcastle University, UK [http://www.ncl.ac.uk/camb/staff/profile/jeff.errington homepage]References
Reviews
Original publications
8606187,15262952,9721295,10322023,7814321,18363795,14731276,21320184,18763711,19192185,18179421,23531131,18363795